Daphne Koller

Founder and CEO of insitro

About

Daphne Koller is founder and CEO of insitro, a machine learning-driven drug discovery company.

Daphne co-founded Coursera and Engageli, was chief computing officer at Calico, and is an adjunct faculty member at Stanford.

Daphne earned a PhD in computer science at Stanford and an MSc in computer science at the Hebrew University of Jerusalem.

Experience

Education

At a glance

  • Co-founded Coursera, an online education platform

  • Co-founded Engageli, an interactive learning platform

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Work

www.insitro.com · 2026-11-12

  • insitro uses machine learning in drug discovery and development.
  • Daphne was Rajeev Motwani Professor of computer science at Stanford University.

Projects

engineering.stanford.edu · 2026-11-12

  • At insitro, the platform uses machine learning to explore disease causes and possible treatments.

www.insitro.com · 2026-11-12

  • Coursera is an online education platform that has reached over 100 million learners.
  • Engageli is an interactive digital learning platform.

observer.com · 2026-11-12

  • Daphne's team added checks to its AI pipeline after questioning the data behind a prioritized drug target.
  • In 2026, insitro's collaborations included an ALS program with Bristol Myers Squibb and a metabolic disease program with Eli Lilly.
  • insitro's Virtual Human platform supplied additional ALS targets for the Bristol Myers Squibb collaboration.
  • insitro presented preclinical mouse data for its CTRO-1013 candidate in 2026.

Writing

www.insitro.com · 2026-11-12

  • Daphne has authored more than 300 refereed publications.

Education

  • Daphne earned a Bachelor of Science in computer science and mathematics at the Hebrew University of Jerusalem.

Recognition

www.insitro.com · 2026-11-12

  • Daphne received a MacArthur Foundation Fellowship in 2004.
  • Daphne received the ACM Prize in Computing in 2008.
  • Daphne received the ACM AAAI Allen Newell Award in 2019.
  • Daphne was inducted into the National Academy of Engineering in 2011 and the National Academy of Science in 2023.
  • Daphne was elected a fellow of the American Association for Artificial Intelligence in 2004, the American Academy of Arts and Sciences in 2014 and the International Society of Computational Biology in 2017.
  • Daphne received the Sloan Foundation Faculty Fellowship in 1996, the ONR Young Investigator Award in 1998, and PECASE in 1999.
  • Daphne received the IJCAI Computers and Thought Award in 2001 and the AnitaB.org Technical Leadership Abie Award in 2022.
  • Daphne was recognized with the Stanford Medal for Excellence in Fostering Undergraduate Research and as a Bass University Fellow in Undergraduate Education.

Views

observer.com · 2026-11-12

  • Daphne discusses the importance of distinguishing causal relationships from statistical associations in drug discovery.

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