About
Daphne Koller is founder and CEO of insitro, a machine learning-driven drug discovery company.
Daphne co-founded Coursera and Engageli, was chief computing officer at Calico, and is an adjunct faculty member at Stanford.
Daphne earned a PhD in computer science at Stanford and an MSc in computer science at the Hebrew University of Jerusalem.
Experience
insitroFounder and CEO2018 – Present
EngageliCo-Founder and Board MemberFrom 2020
CourseraCo-Founder and Co-Chairman2016 – 2019
Calico Life SciencesChief Computing Officer2016 – 2018
CourseraCo-Founder and President2014 – 2016
CourseraCo-Founder and Co-Chief Executive Officer2012 – 2014
Stanford UniversityProfessor1995 – 2014
Stanford UniversityAdjunct faculty member
Education
At a glance
Co-founded Coursera, an online education platform
Co-founded Engageli, an interactive learning platform
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Work
- insitro uses machine learning in drug discovery and development.
- Daphne was Rajeev Motwani Professor of computer science at Stanford University.
Projects
engineering.stanford.edu · 2026-11-12
- At insitro, the platform uses machine learning to explore disease causes and possible treatments.
- Coursera is an online education platform that has reached over 100 million learners.
- Engageli is an interactive digital learning platform.
- Daphne's team added checks to its AI pipeline after questioning the data behind a prioritized drug target.
- In 2026, insitro's collaborations included an ALS program with Bristol Myers Squibb and a metabolic disease program with Eli Lilly.
- insitro's Virtual Human platform supplied additional ALS targets for the Bristol Myers Squibb collaboration.
- insitro presented preclinical mouse data for its CTRO-1013 candidate in 2026.
Writing
- Daphne has authored more than 300 refereed publications.
Education
- Daphne earned a Bachelor of Science in computer science and mathematics at the Hebrew University of Jerusalem.
Recognition
- Daphne received a MacArthur Foundation Fellowship in 2004.
- Daphne received the ACM Prize in Computing in 2008.
- Daphne received the ACM AAAI Allen Newell Award in 2019.
- Daphne was inducted into the National Academy of Engineering in 2011 and the National Academy of Science in 2023.
- Daphne was elected a fellow of the American Association for Artificial Intelligence in 2004, the American Academy of Arts and Sciences in 2014 and the International Society of Computational Biology in 2017.
- Daphne received the Sloan Foundation Faculty Fellowship in 1996, the ONR Young Investigator Award in 1998, and PECASE in 1999.
- Daphne received the IJCAI Computers and Thought Award in 2001 and the AnitaB.org Technical Leadership Abie Award in 2022.
- Daphne was recognized with the Stanford Medal for Excellence in Fostering Undergraduate Research and as a Bass University Fellow in Undergraduate Education.
Views
- Daphne discusses the importance of distinguishing causal relationships from statistical associations in drug discovery.
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